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Iron-deficiency anaemia

J D Cook1

  • 1Section of Haematology, University of Kansas Medical Center, Kansas City 66160.

Bailliere'S Clinical Haematology
|December 1, 1994
PubMed
Summary
This summary is machine-generated.

Iron-deficiency anaemia (IDA) is a global health issue. Diagnosing IDA involves assessing hemoglobin and ferritin levels, with serum transferrin receptor tests aiding differentiation from other anemias.

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Area of Science:

  • Hematology
  • Public Health
  • Clinical Diagnostics

Background:

  • Iron-deficiency anaemia (IDA) is a prevalent global health concern, particularly in developing nations.
  • Laboratory diagnosis typically relies on low hemoglobin and serum ferritin, but normal ferritin does not exclude IDA.
  • Bone marrow examination is often used when serum ferritin is normal in suspected IDA.

Purpose of the Study:

  • To review diagnostic approaches for IDA.
  • To highlight the utility of serum transferrin receptor measurements.
  • To discuss physiological causes and management strategies for IDA.

Main Methods:

  • Review of diagnostic markers for IDA, including hemoglobin, serum ferritin, and serum transferrin receptor.
  • Identification of common physiological causes of IDA.

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  • Discussion of treatment options for IDA.

    • Main Results:

    • Serum transferrin receptor levels are elevated in IDA and normal in anemia of chronic disease, aiding differential diagnosis.
    • Physiological causes include growth, blood loss, pregnancy, donation, training, aspirin use, and vegetarian diets.
    • Most IDA cases respond to oral iron, with alternative delivery systems available for side effects.

    Conclusions:

    • Accurate diagnosis of IDA is crucial, with serum transferrin receptor offering a valuable tool.
    • Awareness of physiological causes and potential gastrointestinal blood loss is essential.
    • Effective management involves oral iron therapy, with options for improved tolerance and absorption.