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Urinary element concentrations in kidney stone formers and normal controls: the week-end effect
Journal of Trace Elements and Electrolytes in Health and Disease
|June 1, 1994
Summary
Healthy individuals show elevated urinary elements on Mondays, a "weekend effect," unlike stone-formers. This highlights the importance of urine collection timing for accurate health assessments.
Area of Science:
- Nephrology
- Analytical Chemistry
- Biochemistry
Background:
- Urinary element concentrations are crucial for understanding kidney stone formation.
- Variability in daily measurements can obscure underlying physiological differences.
- The impact of weekly cycles on urinary composition is not well-understood.
Purpose of the Study:
- To investigate daily variations in urinary element concentrations.
- To compare excretion patterns between healthy controls and male kidney stone formers.
- To identify potential
Main Methods:
- Collected early morning urines over three consecutive days (Monday-Wednesday).
- Quantified 10 elements using advanced spectroscopic techniques (ICP-AES, GFAAS, PIXE).
- Analyzed data with multivariate statistical methods.
Main Results:
- Healthy controls exhibited significantly higher urinary element concentrations on Mondays.
- Differences in specific elements were observed between controls and stone formers, particularly on Mondays.
- This phenomenon was termed the
Conclusions:
- A