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Construction of human Y-chromosomal haplotypes using a new polymorphic A to G transition
M T Seielstad1, J M Hebert, A A Lin
1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138.
Human Molecular Genetics
|December 1, 1994
Abstract:
We report the discovery of a polymorphic A to G transition found on the human Y chromosome by sequencing Y-specific sequence-tagged sites (STSs). It shows maximal linkage disequilibrium with a previously described Alu insertional polymorphism. We analyze further an apparently African Y chromosome which seems to have entered a Mexican Mayan population several generations ago. Using the newly discovered transition and the Y-specific polymorphic Alu insertion, we discuss how the chromosome's haplotype information might be used to answer questions of human origins and migrations.