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Basic fibroblast growth factor increases cortical blood flow in vivo
L Regli1, R E Anderson, F B Meyer
1Thoralf M. Sundt Jr. Neurosurgical Research Laboratory, Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905.
Brain Research
|November 28, 1994
Summary
Basic fibroblast growth factor (FGF) increases blood flow in the brain. This study shows topical application of bFGF boosts regional cortical blood flow (rCBF) in rabbits.
Area of Science:
- Neuroscience
- Physiology
- Cardiovascular Research
Background:
- Basic fibroblast growth factor (FGF) is known to induce vasodilation.
- Previous research suggests bFGF may impact cerebral blood flow.
Purpose of the Study:
- To investigate the effect of basic FGF on regional cortical blood flow (rCBF).
- To test the hypothesis that bFGF increases rCBF.
Main Methods:
- Regional cortical blood flow (rCBF) and brain intracellular pH (pHi) were measured in rabbits.
- bFGF or a vehicle control was superperfused onto the rabbit cortex.
Main Results:
- Topical application of bFGF resulted in a significant increase in rCBF.
- No significant changes in brain pHi were reported in relation to bFGF application.
Conclusions:
- Basic FGF demonstrably increases regional cortical blood flow.
- bFGF represents a potential therapeutic agent for conditions involving impaired cerebral perfusion.