A technique for liver transplantation in the inbred mouse

The technique of liver grafting to the kidney of inbred mice was used to characterise ultrastructurally liver rejection under controlled conditions. Electron microscopy showed that liver rejection was initiated by intimate contract between the hepatocytes and the infiltrating large lymphoid cells and brought about by means of narrow cytoplasmic processes extended from the latter. This was prevented by ATS-immunosuppressive treatment.