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Updated: Aug 12, 2026

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes
Published on: May 14, 2012
Antigen-induced programmed T cell death as a new approach to immune therapy
1Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Abstract:
We describe recent advances in understanding a mechanism of peripheral tolerance that operates through antigen-induced programmed cell death of mature T lymphocytes. A three-phase model of this process, termed propriocidal regulation, involves: (i) activation of T cells to express growth lymphokines and their receptors, (ii) lymphokine-stimulated cell-cycle progression, and (iii) T cell receptor reengagement leading to programmed cell death. Based on this model, antigen was used to treat experimental allergic encephalomyelitis and caused profound deletion of autoreactive, encephalitogenic T cells as well as dramatic clinical and pathological improvement of the disease. The potential strengths and weaknesses of this approach to the clinical treatment of T-cell-mediated diseases are discussed.
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