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Stuttering induced by theophylline

D B Rosenfield1, M McCarthy, K McKinney

  • 1Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.

Ear, Nose, & Throat Journal
|December 1, 1994
PubMed
Summary
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Theophylline may cause speech dysfluency in children with asthma. Discontinuing the medication resolved the stuttering, suggesting a potential link between theophylline and acquired stuttering.

Area of Science:

  • Pediatric Neurology
  • Pharmacology
  • Speech-Language Pathology

Background:

  • Asthma is a common chronic respiratory disease in children.
  • Theophylline is a bronchodilator used in asthma management.
  • Speech dysfluency, including stuttering, can impact communication and quality of life.

Observation:

  • Three children with asthma experienced new-onset speech dysfluency after theophylline administration.
  • The dysfluency resolved upon cessation of theophylline.
  • Reintroducing theophylline in two children led to the recurrence of dysfluency.

Findings:

  • A potential causal relationship between theophylline and acquired stuttering in susceptible children is suggested.
  • The exact mechanism and classification (acquired vs. developmental stuttering) remain unclear.

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  • Further investigation is warranted to confirm the association and understand the underlying pathophysiology.

    • Implications:

    • Clinicians should be aware of potential speech dysfluency as an adverse effect of theophylline.
    • Prompt evaluation and discontinuation of theophylline may alleviate stuttering symptoms.
    • This observation could inform future research into the pharmacologic basis of stuttering.