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Isolation of a human cerebral imidazoline-specific binding protein
H Greney1, F Bennai, A Molines
1Laboratoire de Pharmacologie Cardiovasculaire et Rénale, C.N.R.S. URA 589, Université Louis Pasteur, Faculté de Médecine, Strasbourg, France.
European Journal of Pharmacology
|November 14, 1994
Abstract:
The first isolation of a human brain specific imidazoline binding protein is described. This protein was obtained using affinity chromatography and was revealed with the aid of an anti-idiotypic antibody specific for imidazoline binding sites. The protein (43 kDa) differs from other imidazoline binding proteins previously isolated from peripheral tissues, in particular by being also sensitive to clonidine.