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Sudomotor dysfunction in amyotrophic lateral sclerosis

M Kihara1, A Takahashi, J Sugenoya

  • 1Department of Internal Medicine, Daini Hospital, Tokyo Women's Medical College, Japan.

Functional Neurology
|July 1, 1994
PubMed
Summary
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Patients with amyotrophic lateral sclerosis (ALS) exhibit mild thermoregulatory sweat dysfunction. This impairment, particularly in the lower extremities, suggests postganglionic sudomotor nerve damage in ALS.

Area of Science:

  • Neurology
  • Physiology
  • Sweat Gland Function

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons.
  • Thermoregulation and sweat gland function are crucial for maintaining body temperature.
  • Sudomotor dysfunction has been an understudied aspect in ALS pathogenesis.

Purpose of the Study:

  • To quantitatively assess sudomotor function in patients with classic amyotrophic lateral sclerosis (ALS).
  • To investigate potential differences in sweat response between ALS patients and healthy controls.
  • To explore the relationship between thermoregulatory challenges and sudomotor abnormalities in ALS.

Main Methods:

  • Quantitative sudomotor axon reflex testing was performed on 11 ALS patients and 11 age-matched controls.

Related Experiment Videos

  • Subjects underwent thermal warming to assess sweat rate.
  • Thyrotropin-releasing hormone was administered to evaluate sweat response and temperature changes.

    • Main Results:

    • Thermal warming stimulated sweat rate in ALS patients' forearms but was reduced in their thighs compared to controls.
    • Thyrotropin-releasing hormone increased sweat rate and decreased oral temperature in both groups, with a blunted lower extremity response in ALS.
    • Sudomotor axon reflex tests indicated mild postganglionic sudomotor dysfunction in the thighs of ALS patients.

    Conclusions:

    • Patients with amyotrophic lateral sclerosis demonstrate mild thermoregulatory sweat dysfunction.
    • The findings suggest postganglionic sudomotor nerve lesions, particularly in the lower extremities, contribute to this dysfunction in ALS.
    • Sudomotor assessment may offer insights into the peripheral nerve involvement in ALS.