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Intraluminal gastric pH in chronic pancreatitis
P Bovo1, G Cataudella, V Di Francesco
1Institute of Clinical Medicine, University of Verona, Italy.
Gut
|February 1, 1995
Summary
Patients with severe chronic pancreatitis exhibit increased gastric acidity during digestion. This highlights a significant link between impaired pancreatic function, digestion, and stomach acid levels in chronic pancreatitis.
Area of Science:
- Gastroenterology
- Physiology
Background:
- Chronic pancreatitis (CP) is a complex condition affecting digestion.
- Understanding intragastric pH variations is crucial for managing CP.
Purpose of the Study:
- To investigate circadian variations in intragastric pH.
- To correlate gastric acidity with the severity of exocrine pancreatic insufficiency in CP patients.
Main Methods:
- 24-hour intragastric pH monitoring using a monocrystalline antimony electrode.
- Secretin-caerulein test to assess exocrine pancreatic function.
- Patients categorized into severe insufficiency (CP-SI), mild insufficiency (CP-MI), and normal function (CP-NF) groups.
Main Results:
- CP-SI patients showed significantly higher gastric acidification in postprandial periods compared to controls (P1: p < 0.001; P2: p < 0.01).
- CP-SI patients also had greater postprandial gastric acidity than CP-MI and CP-NF groups combined (P1: p < 0.01; P2: p < 0.05).
Conclusions:
- Gastric acidity is closely related to exocrine pancreatic insufficiency and impaired digestion in chronic pancreatitis.
- The findings suggest a pathophysiological link between pancreatic exocrine function and gastric acid secretion.
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