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Related Experiment Videos

[Exogenous effects on ACTH and cortisol secretion]

T H Schürmeyer1

  • 1Abteilung Klinische Endokrinologie, Zentrum Innere Medizin und Dermatologie der Medizinischen Hochschule Hannover.

Fortschritte Der Medizin
|January 20, 1995
PubMed
Summary
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Human corticotropic hormone (ACTH) and cortisol are secreted episodically, influenced by daily rhythms, sleep, and external factors. Medications and neurotransmitters like serotonin can modulate their release.

Area of Science:

  • Endocrinology
  • Neuroscience

Background:

  • Human corticotropic hormone (ACTH) and cortisol secretion are crucial endocrine functions.
  • Recent advancements in hormone measurement enable detailed study of their release patterns.

Purpose of the Study:

  • To investigate the episodic and parallel secretion of ACTH and cortisol in humans.
  • To identify exogenous factors influencing the daily rhythm and liberation of these hormones.

Main Methods:

  • Utilized sensitive assays for measuring ACTH and cortisol levels.
  • Observed hormonal secretion patterns in relation to various physiological and environmental factors.

Main Results:

  • ACTH and cortisol exhibit episodic and parallel secretion patterns.

Related Experiment Videos

  • Secretion is modulated by circadian rhythms, meals, physical activity, stress, and sleep (including REM sleep).
  • Specific drugs (phenytoin, ketoconazole, cyproterone acetate) affect cortisol; opiates and diazepam affect ACTH.

    • Conclusions:

    • Daily rhythms and external factors significantly influence ACTH and cortisol secretion.
    • Neurotransmitters like serotonin and antagonists such as cyproheptadine, along with glucocorticoids, play a role in regulating CRH and ACTH release.