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Carbohydrate malabsorption in acute diarrhea

M Karaböcüoglu1, S Sökücü, G Gökçay

  • 1Institute of Child Health, University of Istanbul, Turkey.

Indian Pediatrics
|September 1, 1994
PubMed
Summary

Carbohydrate malabsorption affects 11% of infants with acute diarrhea, often without clear intolerance symptoms. Intestinal absorption defects are not specific to lactose, impacting overall carbohydrate digestion.

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Area of Science:

  • Pediatrics
  • Gastroenterology
  • Nutritional Science

Background:

  • Acute diarrhea is a common pediatric illness.
  • Carbohydrate malabsorption can contribute to prolonged diarrhea in infants.
  • Early diagnosis and management are crucial for infant health.

Purpose of the Study:

  • To investigate the prevalence of carbohydrate malabsorption in well-nourished infants with acute diarrhea.
  • To assess the clinical presentation of carbohydrate intolerance in this population.
  • To identify specific carbohydrate absorption defects.

Main Methods:

  • Screening of 245 infants using stool pH and reducing substances.
  • Diagnosis of carbohydrate malabsorption based on specific criteria.
  • Oral lactose tolerance tests performed on a subset of infants.

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  • Thin layer chromatography used to analyze stool carbohydrate composition.

    • Main Results:

    • Carbohydrate malabsorption was diagnosed in 11% (28/245) of infants.
    • Only one infant presented with clear clinical features of carbohydrate intolerance.
    • Lactase deficiency was indicated in 32% of cases via oral lactose tolerance tests.
    • Thin layer chromatography revealed diverse monosaccharides in stools, suggesting non-specific absorption defects.

    Conclusions:

    • Carbohydrate malabsorption is prevalent in infants with acute diarrhea, often presenting subtly.
    • Clinical symptoms of intolerance do not always correlate with diagnosed malabsorption.
    • Intestinal absorption defects in these infants are frequently not limited to lactose, implying broader carbohydrate digestion issues.