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Related Experiment Videos

Expression of E-cadherin during craniofacial development

C Lüning1, A Rass, B Rozell

  • 1Department of Cell Biology, Medical Nobel Institute, Stockholm, Sweden.

Journal of Craniofacial Genetics and Developmental Biology
|October 1, 1994
PubMed
Summary
This summary is machine-generated.

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E-cadherin, a key cell adhesion molecule, is crucial for craniofacial development, including palate and tooth formation. Its expression increases with differentiation, highlighting its role in normal embryonic development.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Craniofacial Development

Background:

  • Cell adhesion molecules are vital for tissue formation.
  • E-cadherin is a critical cell adhesion molecule implicated in organogenesis and histogenesis.

Purpose of the Study:

  • To investigate the role of E-cadherin in normal and disturbed craniofacial development.
  • To analyze E-cadherin presence during palate and tooth formation.

Main Methods:

  • Immunohistochemistry using a rat monoclonal antibody (DECMA-1).
  • In situ hybridization using an oligonucleotide probe.
  • Analysis of normal and retinoic acid-induced cleft palate fetuses (gestational days 14-18).

Main Results:

Related Experiment Videos

  • E-cadherin was detected in ectodermal and endodermal epithelia, including developing teeth and palate.
  • Expression levels increased with embryonic age and differentiation.
  • Higher E-cadherin expression was observed in oral epithelia compared to nasal epithelia in 18-day-old fetuses.

    • Conclusions:

    • E-cadherin expression patterns suggest a significant role in the normal development of craniofacial complex epithelia.
    • This molecule is important for palate and tooth development during embryogenesis.