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Antibiotic resistance of clinical isolates of Streptococcus pneumoniae in Greece
S Kanavaki1, S Karabela, E Marinis
1Laboratory of Clinical Microbiology, Chest Hospital, Athens, Greece.
Abstract:
The antibiotic susceptibilities of 1,002 Streptococcus pneumoniae clinical isolates from patients with community-acquired pneumonia were determined over an 18-month period. Resistance rates were 14% for penicillin, 20% for erythromycin, 26% for tetracycline, and 1% for chloramphenicol. Resistance to non-beta-lactam antibiotics was associated with penicillin resistance at statistically levels.
Insights
Antibiotic resistance in Streptococcus pneumoniae is a growing concern for community-acquired pneumonia. This study found significant resistance rates to common antibiotics like penicillin and erythromycin.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Pharmacy
Background:
- Community-acquired pneumonia (CAP) poses a significant public health challenge.
- Streptococcus pneumoniae is a primary causative agent of CAP.
- Antibiotic resistance in S. pneumoniae complicates treatment and impacts patient outcomes.
Purpose of the Study:
- To determine the antibiotic susceptibility patterns of clinical isolates of Streptococcus pneumoniae.
- To assess the prevalence of resistance to key antibiotics used in treating CAP.
Main Methods:
- Analysis of 1,002 clinical isolates of Streptococcus pneumoniae.
- Determination of antibiotic susceptibility testing over an 18-month period.
- Statistical analysis to identify associations between resistance patterns.
Main Results:
- Penicillin resistance was observed in 14% of isolates.
- Erythromycin resistance was 20%, and tetracycline resistance was 26%.
- Chloramphenicol resistance was low at 1%; resistance to non-beta-lactam antibiotics correlated with penicillin resistance.
Conclusions:
- Significant levels of antibiotic resistance exist in Streptococcus pneumoniae causing CAP.
- Penicillin and erythromycin resistance are notable concerns.
- Monitoring antibiotic susceptibility is crucial for effective CAP management.