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Plasma beta-endorphin levels and childhood intussusception
S P Ros1, S L Reynolds, D M Bhisitkul
1Department of Pediatrics, Loyola University Medical Center, Maywood, Illinois 60153.
The Journal of Emergency Medicine
|November 1, 1994
Summary
Childhood intestinal intussusception is not linked to higher plasma beta-endorphin levels. This study found no significant difference in beta-endorphin levels between children with and without intussusception.
Area of Science:
- Pediatric Gastroenterology
- Endocrinology
- Biochemistry
Background:
- Intestinal intussusception is a common pediatric surgical emergency.
- The role of endogenous opioids, such as beta-endorphin, in intussusception is not well understood.
Purpose of the Study:
- To investigate the association between plasma beta-endorphin levels and childhood intestinal intussusception.
Main Methods:
- Prospective study of 14 pediatric patients presenting with intussusception symptoms.
- Plasma beta-endorphin levels measured by radioimmunoassay.
- Diagnosis confirmed or excluded by barium enema.
Main Results:
- Mean beta-endorphin level in 8 patients with intussusception was 14.1 pg/ml.
- Mean beta-endorphin level in 5 patients without intussusception was 18.1 pg/ml.
- No statistically significant difference in beta-endorphin levels was observed (P = 0.56).
Conclusions:
- Childhood intestinal intussusception is not associated with elevated plasma beta-endorphin levels.
- Plasma beta-endorphin levels do not appear to be a reliable biomarker for diagnosing intussusception in children.