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Review of the macrophage disappearance reaction
M W Barth1, J A Hendrzak, M J Melnicoff
1Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
Abstract:
Macrophages (M phi s) undergo a physiological response known as the macrophage disappearance reaction (MDR) in response to certain stimuli in the peritoneal compartment. The types of stimuli that can cause the MDR, the relationship of the MDR to the host immunological response, and the possible role of the MDR in M phi activation are reviewed. The data indicate that the MDR occurs in response to both acute nonspecific inflammatory and specific immune delayed hypersensitivity processes and that the MDR may play an important role in M phi activation.
Insights
The macrophage disappearance reaction (MDR) is a physiological response in macrophages (M phi s) triggered by inflammatory or immune stimuli. This review suggests MDR plays a key role in macrophage activation.
Area of Science:
- Immunology
- Cell Biology
Background:
- Macrophages (M phi s) are key immune cells.
- The macrophage disappearance reaction (MDR) is a known physiological response.
Purpose of the Study:
- To review stimuli causing MDR.
- To explore MDR's link to host immunity.
- To investigate MDR's role in M phi activation.
Main Methods:
- Literature review of studies on MDR.
- Analysis of stimuli triggering MDR.
- Examination of MDR's immunological context.
Main Results:
- MDR is induced by both acute nonspecific inflammation and specific immune delayed hypersensitivity.
- Evidence suggests a significant role for MDR in M phi activation.
Conclusions:
- MDR is a complex response to diverse stimuli.
- MDR is implicated as a crucial factor in macrophage activation.