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The evidence for soybean products as cancer preventive agents

A R Kennedy1

  • 1Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104.

The Journal of Nutrition
|March 1, 1995
PubMed

Insights

Soybean compounds show promise in cancer prevention. Specific components like Bowman-Birk inhibitor and phytic acid suppress carcinogenesis in animal models, potentially reducing human cancer rates.

Area of Science:

  • Nutritional Science
  • Oncology
  • Biochemistry

Background:

  • Soybean consumption is linked to lower cancer mortality rates, especially for colon, breast, and prostate cancers.
  • While epidemiological evidence is strong, data on specific soybean compounds' anti-cancer mechanisms is less established.

Purpose of the Study:

  • To review the evidence for specific soybean-derived compounds exhibiting cancer-preventive effects.
  • To identify isolated soybean compounds with demonstrated suppressive effects on carcinogenesis in vivo.

Main Methods:

  • Literature review of studies investigating soybean compounds and their effects on cancer.
  • Analysis of in vivo data from animal models examining specific soybean-derived products.

Main Results:

  • Isolated soybean compounds, including Bowman-Birk inhibitor, inositol hexaphosphate (phytic acid), and beta-sitosterol, have shown suppressive effects on carcinogenesis in animal models.
  • Soybean isoflavones, soybean trypsin inhibitor, saponins, and genistein also exhibit potential anticarcinogenic activity.

Conclusions:

  • Specific soybean-derived compounds possess demonstrable anti-carcinogenic properties in preclinical models.
  • Dietary supplementation with these identified soybean products could significantly lower human cancer mortality rates.

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