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Related Experiment Videos

[Digoxin concentration in blood]

R Fushimi1, N Amino

  • 1Central Laboratory for Clinical Investigation, Osaka University Hospital, Suita.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

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The popular Chinese medicine KYUSHIN tablet contains digoxin-like compounds, potentially interfering with digoxin drug monitoring. Careful interpretation is needed for patients using this herbal remedy.

Area of Science:

  • Pharmacology
  • Analytical Chemistry
  • Traditional Chinese Medicine

Context:

  • KYUSHIN, a popular Japanese herbal medicine, contains Ch'an-su, a component with cardiotonic properties.
  • Digoxin immunoassays are widely used for therapeutic drug monitoring.

Purpose:

  • To investigate the presence and quantification of digoxin-like immunoreactivity in KYUSHIN tablets.
  • To assess the potential interference of KYUSHIN with digoxin measurements.

Summary:

  • Immunoreactive digoxin-like activity was detected in KYUSHIN tablets, with varying equivalencies (1.5-72 µg/tablet) across different immunoassay analyzers due to antibody cross-reactivity.
  • In healthy volunteers, typical KYUSHIN dosage resulted in detectable digoxin-like immunoreactivity in serum.
  • A newer chemiluminescent immunoassay showed low or undetectable digoxin-like immunoreactivity in KYUSHIN extracts and serum.

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Impact:

  • Highlights the need for caution when interpreting digoxin levels in patients using KYUSHIN or other traditional medicines containing Ch'an-su.
  • Suggests that assay methodology and antibody specificity influence the detection of digoxin-like substances.
  • Emphasizes the importance of considering herbal medicine use in therapeutic drug monitoring.