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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

The movement disorder of adult opsoclonus

J N Caviness1, P A Forsyth, D D Layton

  • 1Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 1, 1995
PubMed

Insights

Adult opsoclonus-myoclonus syndrome can be a sign of systemic carcinoma. Early recognition is crucial for diagnosing occult malignancy and improving patient prognosis.

Area of Science:

  • Neurology
  • Oncology

Background:

  • Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disorder.
  • It is characterized by involuntary, rapid eye movements (opsoclonus) and muscle jerks (myoclonus).

Observation:

  • This study presents three adult cases of OMS associated with systemic carcinoma.
  • Clinical manifestations included ataxia, tremor, gait disturbances, altered mental status, and dyskinesias.

Findings:

  • Pathological and radiographic evidence points to brainstem dysfunction, often with cerebellar involvement.
  • Immunologic and inflammatory processes are implicated in the syndrome's pathogenesis.

Implications:

  • The presence of OMS in adults warrants a thorough search for an occult malignancy.
  • Timely diagnosis is critical for determining underlying etiology and prognosis.

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