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[Anemia and erythropoietin level in some hematology malignancies]
M Rokicka-Piotrowicz1, M Paszkowska, Z Kuratowska
1Klinika Hematologii Akademii Medycznej w Warszawie.
Unlabelled:
Pathogenesis of anemia in patients with myeloma, low grade lymphoma and acute leukaemia was the aim of the study. Erythropoietin (Epo) serum level was detected according to ELISA test. Significant increase of Epo serum level in 13 myeloma and 30 low grade lymphoma patients was found. In 21 acute leukemia cases the Epo serum level was significantly increased (disproportional to Hb concentration).
Conclusion:
in the studied myeloma and low grade lymphoma patients anemia did not depend on defective Epo secretion. Significant increase of Epo serum level in acute leukaemia, strongly suggested additional stimulation mechanism for hormone synthesis. Further studies of this mechanism are needed.