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Mixed prostatic carcinoma containing malignant squamous element. Reports of two cases
M Ishigooka1, H Yaguchi, M Tomaru
1Department of Urology, Yamagata University, School of Medicine, Japan.
Scandinavian Journal of Urology and Nephrology
|December 1, 1994
Summary
Mixed prostatic carcinoma presents unique challenges. One patient with urothelial and squamous cell carcinoma had a poor outcome, while another with adenosquamous carcinoma responded well to treatment.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Prostatic carcinoma encompasses various histological subtypes.
- Mixed prostatic carcinomas, combining different cell types, present unique diagnostic and therapeutic challenges.
Observation:
- Report of two cases of mixed prostatic carcinoma.
- Case 1: A 67-year-old male with mixed urothelial and squamous cell carcinoma.
- Case 2: A 70-year-old male with adenosquamous carcinoma.
Findings:
- The patient with mixed urothelial and squamous cell carcinoma experienced disease progression and mortality within 10 months, despite hormonal therapy and pelvic irradiation.
- The patient with adenosquamous carcinoma demonstrated a favorable response to hormonal therapy and pelvic irradiation.
Implications:
- Histological subtype significantly influences treatment response and prognosis in mixed prostatic carcinoma.
- Further research is warranted to elucidate optimal treatment strategies for diverse mixed prostatic carcinoma subtypes.