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The safe blood components for a hemophilia patient: a case report
A Chuansumrit1, S Pandhawong, P Tardtong
1Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Insights
This study details safe blood component preparation for a child with hemophilia A, utilizing carefully screened donors. Parent involvement in donor recruitment ensures a reliable supply of high-quality blood products.
Area of Science:
- Hematology
- Pediatric Medicine
- Blood Transfusion
Background:
- Hemophilia A management in children requires consistent access to safe blood products.
- Early and continuous blood product transfusion is critical for managing hemophilia A from infancy.
- Home therapy initiation at age three aids in long-term hemophilia A care.
Observation:
- Fresh dry plasma (FDP) was prepared from 8-10 healthy, screened donors (parents, relatives, friends aged 30-45).
- Donors underwent at least two negative anti-HIV tests before FDP utilization.
- Cryoprecipitate collection via plasmapheresis from parents began in 1990, yielding 12-15 bags per session.
Findings:
- Selected donors and rigorous screening protocols enhance blood component safety.
- Parental involvement in donor recruitment effectively addresses blood donor shortages.
- Prepared blood components contribute to improved quality of care for pediatric hemophilia A patients.
Implications:
- This approach offers a model for ensuring safe and adequate blood supply for children with hemophilia.
- Parental engagement in donor recruitment can be a sustainable strategy for managing rare blood product needs.
- Enhanced quality of blood components supports better clinical outcomes in pediatric hemophilia management.
Abstract:
This study comments on safe blood components prepared for a 6 year old boy with hemophilia A (F VIII:C 1.8%). He has required blood transfusion since 10 months of age and started home therapy since 3 years of age. The utilized blood components were fresh dry plasma (FDP) prepared from 8-10 selected donors who were in good health and had no risk of blood-transmitted diseases. They were parents, relatives and friends with the age ranging from 30-45 years old. The FDP would be used after the donors had at least two subsequent negative tests for anti-HIV. In addition, cryoprecipitate collected from parents by plasmapheresis was started in 1990. Twelve to fifteen bags of cryoprecipitate were collected each plasmapheresis. The blood components prepared from the selected donors is an additional management to obtain the better quality of blood. Moreover, the role of parents taking the major responsibility in the recruitment of donors will minimize the shortage of blood donors.