Immunoglobulins in acquired platelet dysfunction with eosinophilia

Acquired platelet dysfunction with eosinophilia (APDE) is acquired bleeding diathesis associated with platelet dysfunction causing prolonged bleeding time. Most of them had eosinophilia. Various reports of the isolated cases had normal level of immunoglobulins but few had increased IgE. This report is different from others in that among 41 cases of APDE, it was found that most of them had normal levels of IgG, IgA, IgE but there was increased IgM in 95.1% of the cases. Increased in IgE was noticed in 7/24 cases (29.2%) and only half (3/6 cases) corresponded with eosinophilia.