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Related Experiment Videos

Immunoglobulins in acquired platelet dysfunction with eosinophilia

P Hathirat1, P Isarangkura, P Pintadit

  • 1Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

The Southeast Asian Journal of Tropical Medicine and Public Health
|January 1, 1993
PubMed
Summary

Acquired platelet dysfunction with eosinophilia (APDE) is a bleeding disorder. This study found most APDE patients have elevated IgM, unlike previous reports focusing on IgE.

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Area of Science:

  • Hematology
  • Immunology
  • Clinical Medicine

Background:

  • Acquired platelet dysfunction with eosinophilia (APDE) is a rare bleeding disorder.
  • APDE is characterized by impaired platelet function and prolonged bleeding time, often with eosinophilia.
  • Previous reports on immunoglobulin levels in APDE are limited and sometimes contradictory.

Purpose of the Study:

  • To investigate immunoglobulin profiles in a cohort of 41 patients with APDE.
  • To determine the prevalence of specific immunoglobulin abnormalities, particularly IgM and IgE, in APDE patients.
  • To correlate immunoglobulin levels with clinical features like eosinophilia.

Main Methods:

  • Retrospective analysis of clinical data from 41 APDE patients.
  • Measurement of serum immunoglobulin levels (IgG, IgA, IgM, IgE).

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  • Correlation of immunoglobulin levels with presence of eosinophilia and bleeding symptoms.

    • Main Results:

    • Elevated IgM levels were observed in 95.1% of APDE cases.
    • Normal IgG, IgA, and IgE levels were common.
    • Increased IgE was found in 29.2% of cases, with only half correlating with eosinophilia.

    Conclusions:

    • This study highlights a distinct immunoglobulin pattern in APDE, with a high prevalence of elevated IgM.
    • The findings suggest a potential role for IgM dysregulation in the pathogenesis of APDE.
    • Further research is warranted to elucidate the specific mechanisms linking IgM abnormalities to platelet dysfunction and bleeding in APDE.