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Analysis of 75 discarded cadaver kidneys
Archives of Surgery (Chicago, Ill. : 1960)
|October 1, 1976
Summary
Donor pretreatment with specific medications significantly reduced kidney discard rates in transplantation. This finding highlights the importance of donor preparation to improve organ utilization for transplant patients.
Area of Science:
- Nephrology
- Transplantation Immunology
- Surgical Oncology
Background:
- Cadaveric kidney transplantation faces challenges with organ viability.
- A significant number of procured kidneys are discarded due to various factors.
- Optimizing donor conditions is crucial for increasing transplant success rates.
Purpose of the Study:
- To analyze factors influencing the discard of cadaveric kidneys.
- To identify donor-related variables associated with kidney viability for transplantation.
- To evaluate the impact of donor pretreatment on kidney discard rates.
Main Methods:
- Analysis of 431 cadaver kidneys, comparing transplanted and discarded organs.
- Evaluation of donor pretreatment with phenoxybenzamine hydrochloride, methylprednisolone sodium succinate, or phentolaminemesylate.
- Statistical analysis of selected variables between transplanted and discarded kidney groups.
Main Results:
- 75 out of 431 procured kidneys were discarded.
- Reasons for discard included poor flow, multiple arteries, prolonged ischemia, and pump malfunction.
- 70% of transplanted kidneys originated from donors receiving pretreatment, versus only 33.3% of discarded kidneys (P < .01).
Conclusions:
- Donor pretreatment with specific agents is strongly associated with reduced kidney discard.
- Technical aspects of donor nephrectomy and donor pretreatment require careful consideration.
- Implementing donor pretreatment protocols may decrease the number of discarded transplantable kidneys.