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Giant papillary conjunctivitis

P C Donshik

    Transactions of the American Ophthalmological Society
    |January 1, 1994
    PubMed
    Summary
    This summary is machine-generated.

    Giant papillary conjunctivitis (GPC) is a common contact lens complication. Management involves lens material changes, frequent replacement, and adjunctive therapies like mast cell stabilizers for successful contact lens wear.

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    Area of Science:

    • Ophthalmology
    • Ocular Surface Disease
    • Contact Lens Science

    Background:

    • Giant papillary conjunctivitis (GPC) is a frequent complication associated with contact lens wear.
    • Several factors influence the onset and severity of GPC signs and symptoms.

    Purpose of the Study:

    • To investigate the impact of different contact lens types and management strategies on GPC.
    • To identify factors affecting GPC severity and patient tolerance to contact lenses.

    Main Methods:

    • Comparison of GPC severity with rigid gas permeable (RGP) versus soft contact lenses.
    • Evaluation of soft lens materials (ionic vs. nonionic, water content).
    • Assessment of enzymatic cleaning and adjunctive therapies (mast cell stabilizers, NSAIDs).

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    Main Results:

    • RGP lenses showed less severe GPC and a longer onset time compared to soft lenses.
    • Nonionic, low-water-content soft lenses were associated with milder symptoms than ionic counterparts.
    • Enzymatic treatment reduced GPC severity; allergies influenced severity but not final lens wearability.
    • Over 90% success was achieved with strategies like polymer change (e.g., to glyceryl methyl methacrylate), RGP lenses, or frequent replacement soft lenses.

    Conclusions:

    • Contact lens material, type, and replacement schedule significantly impact GPC development and severity.
    • Adjunctive therapies, including mast cell stabilizers and NSAIDs, can help manage persistent GPC symptoms.
    • Effective management strategies allow a high percentage of patients to continue contact lens wear despite GPC history.