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Polyethylene glycol 4000 for slow transit constipation

A G Klauser1, B E Mühldorfer, W A Voderholzer

  • 1Abteilung für Gastroenterologie, Universität Munich, Germany.

Zeitschrift Fur Gastroenterologie
|January 1, 1995
PubMed
Summary

Polyethylene glycol 4000 (PEG) significantly improves slow transit constipation in women. This treatment enhances both subjective well-being and objective colonic function, offering a new option for refractory cases.

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Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Slow transit constipation presents significant treatment challenges.
  • Existing therapies may not be effective for all patients.

Purpose of the Study:

  • To evaluate the efficacy of polyethylene glycol 4000 (PEG) in treating slow transit constipation.
  • To assess PEG's impact on both subjective and objective measures of colonic function.

Main Methods:

  • A randomized, controlled, cross-over study involving eight female outpatients with slow transit constipation.
  • Patients received either placebo or polyethylene glycol 4000 (60g/day) for six weeks each.
  • Measurements included subjective well-being, laxative use, stool frequency, and colonic transit time.

Main Results:

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  • Polyethylene glycol 4000 significantly improved visual analog scale ratings for defecation (p=0.028).
  • Reduced reliance on rescue laxatives (sodium picosulfate) was observed (p=0.028).
  • Stool frequency increased (p=0.017) and total colonic transit time decreased significantly (p=0.017).

Conclusions:

  • Polyethylene glycol 4000 demonstrates significant subjective and objective improvements in colonic function for slow transit constipation.
  • PEG is a viable additional treatment option for patients with refractory slow transit constipation.