Related Experiment Videos
Intradermal anaesthesia: comparison of several compounds
1Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Westfälischen Wilhelms-Universität Münster, Germany.
Acta Anaesthesiologica Scandinavica
|November 1, 1994
Summary
Mepivacaine-1 provided effective intradermal anesthesia for venous cannulation with the least injection discomfort. All tested local anesthetics were superior to saline for pain relief during skin infiltration.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Venous cannulation is a common procedure requiring local anesthesia.
- Assessing patient comfort during local anesthetic infiltration is crucial for procedural success.
Purpose of the Study:
- To compare the efficacy of various local anesthetics in providing intradermal anesthesia for venous cannulation.
- To evaluate the discomfort associated with skin infiltration of these anesthetics.
Main Methods:
- A randomized, double-blind study was conducted with 600 patients (18-65 years, ASA I-II).
- Six preparations (0.9% saline, prilocaine, lidocaine, mepivacaine-1, mepivacaine-2, procaine) were administered intradermally and subcutaneously.
- Pain was assessed using a visual analog scale (VAS) during skin wheal formation and cannula insertion.
Main Results:
- All five local anesthetics demonstrated comparable analgesic efficacy, significantly outperforming 0.9% saline (mean VAS 1.7-2.09 vs. 4.2; P < 0.001).
- Mepivacaine-1 resulted in the least infiltration pain (mean VAS 1.0), while procaine caused the most (mean VAS 2.7; P < 0.001).
Conclusions:
- Mepivacaine-1 is recommended as the preferred local anesthetic for skin infiltration due to minimal injection-related discomfort.
- Effective intradermal anesthesia for venous cannulation can be achieved with several local anesthetics, but Mepivacaine-1 offers superior patient comfort during administration.