Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How double blind is double blind? And does it matter?

E C Huskisson, J Scott

    British Journal of Clinical Pharmacology
    |April 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Four new anti-inflammatory drugs responses and variations.

    The Medical journal of Malaysia·2022
    Same author

    Catecholamine excretion and pain.

    British journal of clinical pharmacology·2012
    Same author

    Indomethacin or amylobarbitone sodium for sleep in rheumatoid arthritis, with some observations on the use of sequential analysis.

    British journal of clinical pharmacology·2012
    Same author

    Modern management of mild-to-moderate joint pain due to osteoarthritis: a holistic approach.

    The Journal of international medical research·2010
    Same author

    Glucosamine and chondroitin for osteoarthritis.

    The Journal of international medical research·2008
    Same author

    Nimesulide, a balanced drug for the treatment of osteoarthritis.

    Clinical and experimental rheumatology·2001
    Same journal

    Anticholinergic and central nervous system-active drug burdens and their associations with adverse in-hospital outcomes among older inpatients.

    British journal of clinical pharmacology·2026
    Same journal

    N-acetylcysteine for non-paracetamol-induced acute liver failure in children: A systematic review and meta-analysis.

    British journal of clinical pharmacology·2026
    Same journal

    Anti-seizure medications and DRESS in paediatric patients: A FAERS disproportionality and time-to-onset analysis.

    British journal of clinical pharmacology·2026
    Same journal

    Modelling immune gene expression profiles as pharmacodynamic endpoints of antileishmanial treatment.

    British journal of clinical pharmacology·2026
    Same journal

    The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone.

    British journal of clinical pharmacology·2026
    Same journal

    Relationship between continuous infusion meropenem PK/PD target attainment and C-reactive protein dynamics in onco-haematologic patients with febrile neutropenia.

    British journal of clinical pharmacology·2026
    See all related articles

    Experienced technicians could often identify treatment periods in a double-blind study, especially for aspirin. This suggests using independent blind observers may improve data integrity by reducing bias in treatment and side-effect collection.

    Area of Science:

    • Clinical trial methodology
    • Pharmacological research
    • Observer bias in research

    Background:

    • Blinding is crucial in clinical trials to prevent bias.
    • Observer bias can compromise the validity of study results.
    • Identifying treatment periods can indicate successful or failed blinding.

    Purpose of the Study:

    • To assess the effectiveness of blinding in a crossover study.
    • To determine if experienced technicians could identify treatment periods.
    • To evaluate the potential for observer bias in clinical trials.

    Main Methods:

    • A double-blind, crossover study design was employed.
    • Experienced measurement technicians attempted to identify treatment periods.
    • Aspirin, known for distinct effects, was one of the treatments used.

    Related Experiment Videos

    Main Results:

    • Technicians were frequently able to identify treatment periods.
    • Aspirin treatment periods were most commonly identified correctly.
    • This indicates potential breaches in blinding integrity.

    Conclusions:

    • The blinding in this study may have been compromised.
    • Using independent blind observers, not involved in treatment or data collection, is recommended.
    • This strategy can enhance the reliability of clinical trial outcomes.