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Increased monocyte tissue factor expression in coronary disease

E W Leatham1, P M Bath, J A Tooze

  • 1Department of Cardiological Sciences, St George's Hospital Medical School, London.

British Heart Journal
|January 1, 1995
PubMed
Summary
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Monocyte tissue factor expression is elevated in patients with acute coronary syndromes and chronic stable angina, contributing to hypercoagulability. This finding highlights tissue factor

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Immunology

Background:

  • Unstable angina and myocardial infarction are linked to increased mononuclear cell procoagulant activity.
  • Monocyte procoagulant activity is primarily mediated by tissue factor (TF) expression.
  • TF initiates the coagulation cascade, suggesting a potential role in ischemic heart disease syndromes.

Purpose of the Study:

  • To determine if monocyte expression of tissue factor (TF) is elevated in patients with acute coronary syndromes (ACS) and chronic stable angina (CSA).
  • To investigate the association between TF expression on monocytes and ischemic heart disease.

Main Methods:

  • A cross-sectional study design was employed.
  • Monocyte TF expression was quantified using flow cytometry with a polyclonal rabbit anti-human TF antibody.

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  • Participants included patients with acute myocardial infarction (AMI), unstable angina (UA), CSA, and healthy controls.

    • Main Results:

    • Significantly higher proportions of monocytes expressing TF were observed in patients with CSA (38%), UA (64%), and AMI (53%) compared to controls (0%).
    • Monocyte TF expression levels were statistically significant across the patient groups (2P = 0.006).
    • Lipopolysaccharide stimulation resulted in similar monocyte TF expression across all subjects, indicating disease-specific upregulation.

    Conclusions:

    • Elevated tissue factor expression on circulating monocytes may contribute to the hypercoagulable state associated with AMI, UA, and CSA.
    • Monocyte TF represents a potential therapeutic target for managing thrombotic complications in ischemic heart disease.