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Increased monocyte tissue factor expression in coronary disease

E W Leatham1, P M Bath, J A Tooze

  • 1Department of Cardiological Sciences, St George's Hospital Medical School, London.

British Heart Journal
|January 1, 1995
PubMed

Insights

Monocyte tissue factor expression is elevated in patients with acute coronary syndromes and chronic stable angina, contributing to hypercoagulability. This finding highlights tissue factor

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Immunology

Background:

  • Unstable angina and myocardial infarction are linked to increased mononuclear cell procoagulant activity.
  • Monocyte procoagulant activity is primarily mediated by tissue factor (TF) expression.
  • TF initiates the coagulation cascade, suggesting a potential role in ischemic heart disease syndromes.

Purpose of the Study:

  • To determine if monocyte expression of tissue factor (TF) is elevated in patients with acute coronary syndromes (ACS) and chronic stable angina (CSA).
  • To investigate the association between TF expression on monocytes and ischemic heart disease.

Main Methods:

  • A cross-sectional study design was employed.
  • Monocyte TF expression was quantified using flow cytometry with a polyclonal rabbit anti-human TF antibody.
  • Participants included patients with acute myocardial infarction (AMI), unstable angina (UA), CSA, and healthy controls.

Main Results:

  • Significantly higher proportions of monocytes expressing TF were observed in patients with CSA (38%), UA (64%), and AMI (53%) compared to controls (0%).
  • Monocyte TF expression levels were statistically significant across the patient groups (2P = 0.006).
  • Lipopolysaccharide stimulation resulted in similar monocyte TF expression across all subjects, indicating disease-specific upregulation.

Conclusions:

  • Elevated tissue factor expression on circulating monocytes may contribute to the hypercoagulable state associated with AMI, UA, and CSA.
  • Monocyte TF represents a potential therapeutic target for managing thrombotic complications in ischemic heart disease.
Abstract

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