Related Experiment Videos
Eosinophilic pustular folliculitis in infancy: report of two affected brothers
A S Dupond1, F Aubin, Y Bourezane
1Department of Functional Dermatology, University Hospital, Besançon, France.
Insights
Two brothers presented with eosinophilic pustular folliculitis, a rare skin condition affecting the scalp. This suggests a potential inherited or contagious factor in the condition's development.
Area of Science:
- Dermatology
- Pediatrics
- Immunology
Background:
- Eosinophilic pustular folliculitis (EPF) is a rare inflammatory skin condition.
- Infantile-onset EPF is exceptionally uncommon, with limited cases reported.
- Understanding the etiology of EPF is crucial for effective management.
Observation:
- Two brothers presented with recurrent papules and pustules on the scalp since infancy.
- Clinical presentation included leukocytosis with marked eosinophilia.
- Histopathology confirmed folliculitis with a predominant eosinophilic infiltrate.
Findings:
- Bacteriological and fungal cultures were negative, ruling out common infections.
- Topical corticosteroids and dapsone showed a good clinical response.
- Review of 28 prior cases of infantile EPF was conducted.
Implications:
- The familial occurrence suggests a possible genetic or contagious predisposition.
- Further research into the pathogenesis of infantile EPF is warranted.
- This case series contributes to the understanding of rare pediatric dermatoses.
Abstract:
We describe two brothers with eosinophilic pustular folliculitis. Both had recurrent crops of papules and pustules, primarily affecting the scalp. The eruption began in the neonatal period. Both children had a leucocytosis with eosinophilia. Histology revealed folliculitis, with an infiltrate in which eosinophils were predominant. Bacteriological and fungal cultures of pustules were negative. There was a good clinical response to treatment with a topical corticosteroid and dapsone. We review the 28 previously reported cases of eosinophilic pustular folliculitis in infancy. The occurrence of this disorder in brothers suggests that an inherited or contagious factor may be involved in its aetiology.