Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Orthostatic hypotension in the aged]

E Lang

    Cardiology
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Orthostatic hypotension, characterized by significant systolic blood pressure drops upon standing, affects many older adults. Dihydroergotamine (DHE) effectively reduced these blood pressure falls and associated dizziness.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Virtual urgent care is here to stay: driving toward safe, equitable, and sustainable integration within emergency medicine.

    CJEM·2024
    Same author

    Emergency care clinical networks.

    CJEM·2022
    Same author

    Safety of elective paediatric surgery during the coronavirus disease 2019 pandemic.

    International journal of pediatric otorhinolaryngology·2021
    Same author

    Outcomes of preoperative real-time polymerase chain reaction testing for SARS CoV-2 in elective otolaryngology surgical patients during the pandemic: a prospective cohort study.

    The British journal of surgery·2021
    Same author

    Influence of concomitant injuries on post-concussion symptoms after a mild traumatic brain injury - a prospective multicentre cohort study.

    Brain injury·2021
    Same author

    Risk of disease transmission from flexible nasoendoscopy during the coronavirus disease 2019 pandemic.

    The Journal of laryngology and otology·2021
    Same journal

    Reply Letter.

    Cardiology·2026
    Same journal

    Aortic Valve Sclerosis: More Than an Incidental Echocardiographic Finding.

    Cardiology·2026
    Same journal

    Can resting segmental strain identify obstructive coronary artery disease in chronic coronary syndrome patients referred to CABG?

    Cardiology·2026
    Same journal

    Mortality Impact of Stroke and Major Bleeding Across the Ejection Fraction Spectrum in Patients Hospitalized for Acute Heart Failure With Prevalent Atrial Fibrillation.

    Cardiology·2026
    Same journal

    Impact of Inflammatory Disorders on Outcomes in Acute Heart Failure: A Nationwide Analysis.

    Cardiology·2026
    Same journal

    Predictors and Clinical Impact of Tricuspid Regurgitation After Pericardiectomy for Constrictive Pericarditis.

    Cardiology·2026
    See all related articles

    Area of Science:

    • Gerontology and Geriatric Medicine
    • Cardiovascular Physiology
    • Clinical Pharmacology

    Background:

    • Postural changes in blood pressure, particularly in older adults, are a significant clinical concern.
    • Previous research indicated substantial systolic blood pressure drops (≥20 mm Hg) in a notable percentage of individuals over 65.
    • The hypodynamic form of orthostatic syndrome, marked by isolated systolic pressure decrease, is linked to age-related circulatory dysregulation.

    Purpose of the Study:

    • To investigate the prevalence and characteristics of posture-dependent blood pressure falls in an elderly population.
    • To evaluate the efficacy of dihydroergotamine (DHE) in managing orthostatic hypotension symptoms.
    • To explore the relationship between circulatory dysregulation and vertigo in old age.

    Main Methods:

    Related Experiment Videos

    • Conducted investigations on 160 residents aged 59-88 in an elderly care facility.
    • Utilized Schellong's test to measure blood pressure and pulse rate changes upon postural transition (supine to standing).
    • Performed a double-blind, cross-over study comparing dihydroergotamine (DHE) (2 mg TID) with placebo in 40 patients over two 14-day treatment periods with a 1-week washout.

    Main Results:

    • Confirmed previous findings, with 25% of subjects exhibiting systolic pressure falls of 20 mm Hg or more using Schellong's test.
    • Dihydroergotamine (DHE) treatment significantly reduced average upright systolic pressure falls from 20 mm Hg (pre-treatment) to 7 mm Hg, compared to placebo (19 mm Hg).
    • DHE significantly decreased the incidence of dizziness during Schellong's test, from 16-17 out of 40 patients (pre-treatment/placebo) to 6 out of 38 patients.

    Conclusions:

    • Age-related deterioration in circulatory regulation is the likely cause of the hypodynamic orthostatic syndrome.
    • Dihydroergotamine (DHE) is an effective therapeutic agent for reducing orthostatic blood pressure drops and associated dizziness in the elderly.
    • Findings provide insights into the etiology of vertigo in the aging population.