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Multiple disseminated meningioma. Case report
K Honczarenko1, H Grzelec, P Nowacki
1Department of Neurology, Medical School, Szczecin.
Abstract:
A case of 32-year-old woman was described in which progressive bilateral hearing and visual loss, hypokinesia, epileptic focal seizures were present. The brain CT-scan after a few years of the disease onset, showed the presence of multiple extracerebral tumors. Multiple meningiomas were diagnosed, probably associated with von Recklinghausen's disease. On the post-mortem examination 48 tumors of the different size and location in subdural space were found. Histologically transitional meningiomas with predominance of fibroblastic component were diagnosed. It was very interesting that apart from intracranial location of meningiomas, the same type of tumor was found within thoracic spinal root. The authors discuss the mechanisms of the development of multiple meningiomas and its association with neurofibromatosis.
Insights
This case study details a 32-year-old woman with progressive neurological symptoms, ultimately diagnosed with multiple meningiomas. The rare finding of tumors both in the brain and spinal cord highlights potential associations with neurofibromatosis.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- This report presents a rare case of a 32-year-old woman with progressive neurological deficits.
- Symptoms included bilateral hearing and visual loss, hypokinesia, and epileptic focal seizures.
Observation:
- Brain CT scans revealed multiple extracerebral tumors years after disease onset.
- Post-mortem examination identified 48 subdural tumors of varying sizes and locations.
- Histological analysis confirmed transitional meningiomas, predominantly fibroblastic.
Findings:
- Multiple meningiomas were diagnosed, with a probable association with von Recklinghausen's disease (neurofibromatosis).
- Unusually, meningiomas were found not only intracranially but also within a thoracic spinal root.
Implications:
- This case underscores the complex presentation and potential systemic involvement of multiple meningiomas.
- Further research into the developmental mechanisms and neurofibromatosis association is warranted.