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Multiple disseminated meningioma. Case report

K Honczarenko1, H Grzelec, P Nowacki

  • 1Department of Neurology, Medical School, Szczecin.

Folia Neuropathologica
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

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This case study details a 32-year-old woman with progressive neurological symptoms, ultimately diagnosed with multiple meningiomas. The rare finding of tumors both in the brain and spinal cord highlights potential associations with neurofibromatosis.

Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • This report presents a rare case of a 32-year-old woman with progressive neurological deficits.
  • Symptoms included bilateral hearing and visual loss, hypokinesia, and epileptic focal seizures.

Observation:

  • Brain CT scans revealed multiple extracerebral tumors years after disease onset.
  • Post-mortem examination identified 48 subdural tumors of varying sizes and locations.
  • Histological analysis confirmed transitional meningiomas, predominantly fibroblastic.

Findings:

  • Multiple meningiomas were diagnosed, with a probable association with von Recklinghausen's disease (neurofibromatosis).
  • Unusually, meningiomas were found not only intracranially but also within a thoracic spinal root.

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Implications:

  • This case underscores the complex presentation and potential systemic involvement of multiple meningiomas.
  • Further research into the developmental mechanisms and neurofibromatosis association is warranted.