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Related Experiment Videos

How do colorectal cancers develop?

S Kuramoto1, T Oohara

  • 1Third Department of Surgery, University of Tokyo, Japan.

Cancer
|March 15, 1995
PubMed
Summary
This summary is machine-generated.

Flat adenomas do not precede flat colorectal cancers. Instead, advanced colorectal cancers primarily develop from flat cancers that arise de novo, not from polyps.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Investigating the origins of colorectal cancer is crucial for effective prevention and treatment strategies.
  • Understanding the distinct pathways of colorectal cancer development is essential.

Purpose of the Study:

  • To determine if flat adenomas are precursors to flat colorectal cancers.
  • To identify the predominant pathway in colorectal cancer development: flat or polypoid cancer.

Main Methods:

  • Histologic examination of 97 flat early cancers, 138 polypoid early cancers, 60 advanced cancers, and 185 flat adenomas.
  • Analysis of clinical features and histological characteristics.

Main Results:

  • Most flat cancers (89.7%) arose de novo, without residual adenoma.

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  • Flat adenomas showed no significant progression to cancer.
  • Advanced cancers resembled flat early cancers in shape, with flat cancers more frequently invading the submucosa than polypoid cancers.

    • Conclusions:

    • Flat adenomas are not precursors of flat colorectal cancers.
    • Colorectal cancer predominantly arises from de novo flat cancers.
    • A minimum of 71.2% of advanced colorectal cancers originate from flat cancers.