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Is trisomy 4 a secondary chromosomal abnormality in acute myeloblastic leukemia?
R Bonomi1, M Le Coniat, R Berger
1INSERM Unité 301, Institut de Génétique Moléculaire, Paris, France.
Cancer Genetics and Cytogenetics
|February 1, 1995
Abstract:
Cytogenetic studies were carried out in a patient with acute monocytic leukemia (AML-M5) at diagnosis and in relapse. While no chromosome abnormality was detected initially, isolated trisomy 4 was found in relapse. The primary or secondary nature of trisomy 4 as the sole abnormality in AML is discussed.