Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Eighty-six cases of Addison's disease

M F Kong1, W Jeffcoate

  • 1Department of Medicine, City Hospital, Nottingham, UK.

Clinical Endocrinology
|December 1, 1994
PubMed
Summary

Addison's disease prevalence in Nottingham is 110 per million, primarily caused by autoimmune adrenal cortex destruction. New diagnostic criteria for the short Synacthen test are proposed based on recent cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of active Charcot disease in the East Midlands of England.

Diabetic medicine : a journal of the British Diabetic Association·2018
Same author

Reducing amputation in diabetes: work from the West Country provides both evidence and a tool-kit.

Diabetic medicine : a journal of the British Diabetic Association·2017
Same author

National Diabetic Foot Audit of England and Wales yields its first dividends.

Diabetic medicine : a journal of the British Diabetic Association·2016
Same author

Pilot study to assess measures to be used in the prospective audit of the management of foot ulcers in people with diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2014
Same author

New national diabetes footcare audit of England and Wales.

Diabetic medicine : a journal of the British Diabetic Association·2014
Same author

Clinical evaluation of a new device in the assessment of peripheral sensory neuropathy in diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2012

Area of Science:

  • Endocrinology
  • Epidemiology
  • Clinical Medicine

Background:

  • Limited recent reviews on Addison's disease necessitate updated epidemiological data.
  • Understanding the prevalence, incidence, and etiology of Addison's disease is crucial for public health planning.

Purpose of the Study:

  • To determine the prevalence, incidence, and causes of Addison's disease in Nottingham.
  • To review and propose updated criteria for interpreting the short Synacthen test in diagnosing Addison's disease.

Main Methods:

  • Retrospective review of hospital case notes for patients diagnosed with Addison's disease between April 1987 and March 1993.
  • Analysis of 86 identified cases, with a focus on the 21 new diagnoses within the study period.

Main Results:

  • Calculated prevalence of Addison's disease at 110 per million population.
  • Autoimmune adrenal cortex destruction identified as the cause in 93% of cases.
  • Incidence of new cases between 1987-1993 was 5.6 per million per annum.

Conclusions:

  • Established new criteria for interpreting the short Synacthen test: baseline cortisol >250 and 30-minute peak >600 nmol/l.
  • Autoimmune etiology is the predominant cause of Addison's disease in the studied population.
  • The study provides current epidemiological data and diagnostic recommendations for Addison's disease.

Related Experiment Videos