Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Immunosuppression and infection]

J Stadler1, C D Heidecke, H Bartels

  • 1Chirurgische Klinik und Poliklinik, Technische Universität München.

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hospital volume and outcome in inguinal hernia repair: analysis of routine data of 133,449 patients.

Hernia : the journal of hernias and abdominal wall surgery·2019
Same author

Comparison of a 3D head-mounted display (HMS-3000MT) and 3D passive polarizing display with 2D technique for first laparoscopic inguinal hernia repair by novice surgeons.

Hernia : the journal of hernias and abdominal wall surgery·2019
Same author

A comparison of non-absorbable polymeric clips and staplers for laparoscopic appendiceal stump closure: analysis of 618 adult patients.

Langenbeck's archives of surgery·2019
Same author

Abnormal bone architecture in mice expressing MyD88 in cells of the osteoclast lineage.

Journal of biological regulators and homeostatic agents·2019
Same author

Randomized study of the influence of two-dimensional versus three-dimensional imaging using a novel 3D head-mounted display (HMS-3000MT) on performance of laparoscopic inguinal hernia repair.

Surgical endoscopy·2018
Same author

Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.

Mucosal immunology·2015

Prolonged sepsis initially activates then suppresses the immune system, leading to organ dysfunction. Understanding this immunosuppression is key to developing new sepsis treatments.

Area of Science:

  • Immunology
  • Pathophysiology
  • Critical Care Medicine

Context:

  • Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
  • Prolonged sepsis involves a complex immune response, shifting from hyperinflammation to profound immunosuppression.
  • Identifying immunosuppressive factors in sepsis is crucial for understanding patient outcomes.

Purpose:

  • To elucidate the mechanisms of immune suppression during prolonged sepsis.
  • To investigate the role of immunosuppressive substances and cellular dysfunction in sepsis progression.
  • To explore potential therapeutic targets for improving sepsis prognosis.

Summary:

  • Prolonged sepsis is marked by an initial immune activation followed by a suppressive state.

Related Experiment Videos

  • Immunosuppressive substances and inhibited immune cell functions are observed in septic patients.
  • This immunosuppression contributes to poor recovery and increased risk of multiple organ dysfunction.

    • Impact:

    • Improved understanding of sepsis pathophysiology.
    • Potential for novel therapeutic strategies to combat sepsis-induced immunosuppression.
    • Enhanced patient outcomes and reduced mortality in prolonged sepsis cases.