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A selective synthesis of 4-aminobiphenyl-N2-deoxyguanosine adducts
S Scheer1, T Steinbrecher, G Boche
1Fachbereich Chemie der Universitat, Marburg, Germany.
Environmental Health Perspectives
|October 1, 1994
Abstract:
A selective synthesis of N2-deoxyguanosine adducts derived from 4-aminobiphenyl (ABP) is described. The reactions of O2-trifluoromethylsulfonyl-O6-allyl-3',5'-O-bis(tert-butyldimethyl silyl)-2'- deoxyxanthosine with 3-amino-4-acetaminobiphenyl and 4-hydrazinobiphenyl, respectively, are the key steps. Successive removal of the protecting groups from the protected adducts leads to the free adducts 3-(deoxyguanosine-N2-yl)-acetyl-ABP and N-(deoxyguanosyl-N2-yl)-ABP, respectively.