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Asprin and codeine in two postpartum pain models

S S Bloomfield, T P Barden, J Mitchell

    Clinical Pharmacology and Therapeutics
    |October 1, 1976
    PubMed
    Summary
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    Aspirin effectively relieved episiotomy and uterine pain, while codeine was only effective for episiotomy pain. This suggests different pain models respond uniquely to analgesics like aspirin and codeine.

    Area of Science:

    • Pharmacology
    • Clinical Trials
    • Pain Management

    Background:

    • Aspirin and codeine are standard positive controls in analgesic clinical trials.
    • Postpartum pain models, such as episiotomy and uterine pain, are crucial for evaluating new analgesics.

    Purpose of the Study:

    • To compare the efficacy of aspirin and codeine against placebo in episiotomy and postpartum uterine pain.
    • To determine the suitability of aspirin and codeine as positive controls in these specific pain models.

    Main Methods:

    • Randomized, parallel, double-blind studies were conducted.
    • Single doses of aspirin (600/1200 mg or 650 mg) and codeine (60 mg) were compared to placebo.
    • Pain intensity difference (PID) scores were used to measure analgesia over time in 99 patients with episiotomy pain and 130 patients with uterine pain.

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    Main Results:

    • Aspirin demonstrated significant analgesia within 1 hour, peaking at 2 hours and lasting up to 5 hours in episiotomy pain.
    • Aspirin also showed good efficacy in postpartum uterine pain.
    • Codeine provided measurable analgesia for episiotomy pain by 2 hours, significant at 4 hours, but was ineffective in uterine pain, showing no difference from placebo.

    Conclusions:

    • Codeine is not a suitable positive control for postpartum uterine pain models.
    • Episiotomy pain is sensitive to both aspirin and codeine.
    • Postpartum uterine pain appears sensitive to aspirin but not codeine, indicating qualitative differences between these pain models.