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Cloning and expression of the cDNA encoding rabbit liver carbonyl reductase
B Gonzalez1, A Sapra, H Rivera
1Division of Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.
Gene
|March 10, 1995
Abstract:
Two cDNA sequences encoding rabbit carbonyl reductase (CBR) were cloned from a lambda gt10 rabbit liver cDNA library. The rabbit cDNAs coded for a protein with 84% identity to human CBR. Transient expression of the two rabbit cDNA sequences in COS7 cells increased both quinone reductase and aldo-keto reductase activities. These data demonstrate that CBR cDNAs from rabbit and human tissues code for similar proteins.