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Age at menarche and first conception in sickle cell hemoglobinopathy
1Regional Medical Research Centre (ICMR), V.S.S. Medical College-Hospital, Sambalpur, Orissa.
Indian Pediatrics
|July 1, 1994
Summary
Sickle cell disease in women is a public health issue. Affected individuals experience a delayed onset of menarche, which consequently impacts their age at first conception.
Area of Science:
- Hematology
- Reproductive Health
- Public Health
Background:
- Sickle cell hemoglobinopathy is a significant public health concern, particularly in tropical regions like India.
- Understanding reproductive health indicators in affected populations is crucial for targeted interventions.
Purpose of the Study:
- To investigate the relationship between sickle cell genotypes and the age at menarche and first conception in women.
- To compare reproductive milestones between women with sickle cell disease and healthy controls.
Main Methods:
- Cross-sectional study comparing age at menarche and first conception.
- Inclusion of women with various sickle cell genotypes and a control group.
Main Results:
- The mean age at menarche was observed to be slightly higher in girls with sickle cell disease compared to controls.
- A delay in the onset of menarche was noted in individuals affected by sickle cell disease.
Conclusions:
- Delayed menarche in sickle cell disease patients can influence their reproductive timelines.
- Further research is warranted to explore the full impact of sickle cell disease on female reproductive health in endemic areas.