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Paracoccidioides brasiliensis-stimulated human gamma/delta T cells support antibody production by B cells
M E Munk1, R A Fazioli, V L Calich
1Department of Immunology, University of Ulm, Germany.
Infection and Immunity
|April 1, 1995
Abstract:
Paracoccidioidomycosis patients show hyperactive humoral immune responses. Consequently, we investigated whether cytokines in supernatants from Paracoccidioides brasiliensis-stimulated gamma/delta T cells support B-cell activation. We detected proliferation of B cells and increased immunoglobulin M (IgM) and IgG production. Thus, gamma/delta T cells may participate in polyclonal B-cell activation during paracoccidioidomycosis.