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Vasoconstrictors during pregnancy--in vitro trial on pregnant and nonpregnant mouse uterus
M T Stepke1, N Schwenzer, W Eichhorn
1Klinik für Kiefer-Gesichts-Chirurgie, Eberhard-Karls-Universität Tübingen, Germany.
International Journal of Oral and Maxillofacial Surgery
|December 1, 1994
Abstract:
In an in vitro trial on 80 pregnant and nonpregnant mice, the sensitivity of the uterus myometrium to the vasoconstrictors vasopressin, ornipressin, epinephrine, and norepinephrine was examined in comparison with oxytocin as a standardized stimulative drug. The pregnant uterus showed a significantly increased sensitivity to ornipressin, vasopressin, and norepinephrine. Epinephrine showed no uterus-stimulating effect, and an increase of sensitivity caused by pregnancy was not detected.