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Mitochondrial DNA damage and efficiency of ATP biosynthesis: mathematical model
1Research Center for Biotechnological Systems SONAR, Ukrainian Academy of Sciences.
Journal of Theoretical Biology
|January 21, 1995
Abstract:
The role of mitochondrial DNA (mtDNA) damage in ageing processes and in malignant transformation of a cell is discussed. A mathematical model of the mtDNA population in a cell and in tissue is constructed. The model describes the effects of mtDNA damages accumulated during ageing and some features of malignant transformation and regeneration.