Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-related decrease in GABAB receptor binding in the Fischer 344 rat inferior colliculus

J C Milbrandt1, R L Albin, D M Caspary

  • 1Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62702.

Neurobiology of Aging
|November 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Body Composition, Falls, and Freezing of Gait in Parkinson's Disease: Gender-Specific Effects.

The Journal of frailty & aging·2024
Same author

Correction to: Noradrenergic cardiac denervation is associated with gait velocity in Parkinson disease: a dual ligand PET study.

European journal of nuclear medicine and molecular imaging·2024
Same author

Noradrenergic cardiac denervation is associated with gait velocity in Parkinson disease: a dual ligand PET study.

European journal of nuclear medicine and molecular imaging·2024
Same author

Cardiac sympathetic denervation and anxiety in Parkinson disease.

Parkinsonism & related disorders·2024
Same author

Predicting Progression from Normal to MCI and from MCI to AD Using Clinical Variables in the National Alzheimer's Coordinating Center Uniform Data Set Version 3: Application of Machine Learning Models and a Probability Calculator.

The journal of prevention of Alzheimer's disease·2023
Same author

Mechanisms of GABAergic and cholinergic neurotransmission in auditory thalamus: Impact of aging.

Hearing research·2020
Same journal

Amygdala and hippocampal volumes as neural correlates of resilience and loneliness in older adults.

Neurobiology of aging·2026
Same journal

Hippocampal-cortical structural networks in the progression of cognitive impairment: A source-based morphometry analysis in individuals with subjective cognitive decline, mild cognitive impairment and Alzheimer's disease.

Neurobiology of aging·2026
Same journal

Brain structure in the cingulate cortex and locus coeruleus in late life is associated with engagement in complex mental activities across the life span.

Neurobiology of aging·2026
Same journal

Age-related differences in motor learning, sensorimotor neurochemistry, and cortical reactivity co-occur but are dissociated.

Neurobiology of aging·2026
Same journal

How cognition and hearing-related measures covary with hippocampal subfield features from structural MRI in younger and older adults.

Neurobiology of aging·2026
Same journal

Decreased awareness of cognitive decline is associated with multimodal Alzheimer's disease biomarkers in cognitively unimpaired individuals.

Neurobiology of aging·2026
See all related articles

Aging significantly reduces GABA-B receptor binding in key brain regions of the inferior colliculus (IC) in rats. This study highlights selective age-related changes in GABA neurotransmitter function within the IC.

Area of Science:

  • Neuroscience
  • Aging Research
  • Neurochemistry

Background:

  • The inferior colliculus (IC) is a crucial auditory processing center in the brain.
  • GABAergic neurotransmission plays a vital role in auditory processing and neural inhibition.
  • Age-related changes in neurotransmitter systems can impact sensory function.

Purpose of the Study:

  • To investigate age-related changes in GABA-B receptor binding within specific subdivisions of the rat inferior colliculus.
  • To compare age-related receptor binding in the IC with a cerebellar region.

Main Methods:

  • Quantitative receptor autoradiography was employed to measure GABA-B receptor binding.
  • [3H]GABA was used as the radioligand, with GABAA receptors blocked by isoguvacine.
  • Binding was assessed in Fischer 344 rats of three age groups: 3, 18-20, and 26 months.

Related Experiment Videos

Main Results:

  • GABA-B receptor binding significantly decreased in the dorsal cortex (DCIC, -44%), external cortex (ECIC, -36%), and central nucleus (CIC, -32%) of aged rats (26 months) compared to young rats (3 months).
  • No significant age-related changes in GABA-B receptor binding were observed in the molecular layer of the cerebellum.
  • The cross-sectional area of the IC did not show significant age-related changes.

Conclusions:

  • The findings demonstrate selective age-related declines in GABA-B receptor binding within the rat inferior colliculus.
  • These results support the hypothesis of specific age-dependent alterations in GABAergic neurotransmission in the IC.
  • The cerebellum did not exhibit similar age-related changes in GABA-B receptor binding, suggesting regional specificity.