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Glutaraldehyde colitis: radiologic findings

B A Birnbaum1, R B Gordon, J E Jacobs

  • 1Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.

Radiology
|April 1, 1995
PubMed
Summary
This summary is machine-generated.

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Glutaraldehyde used in colonoscopy can cause toxic colitis, mimicking ischemia. Radiologic findings on CT scans show colonic wall thickening, resolving with conservative treatment.

Area of Science:

  • Gastroenterology
  • Radiology
  • Toxicology

Background:

  • Two percent glutaraldehyde, a disinfectant, can cause toxic colitis when applied to colonic mucosa.
  • The clinical presentation of this condition can be mistaken for colonic ischemia.

Observation:

  • This retrospective study reviewed four patients with glutaraldehyde-induced colitis over six years.
  • Patients experienced cramps, abdominal pain, tenesmus, and rectal bleeding within 48 hours of colonoscopy.
  • Cultures ruled out enteric pathogens as a cause.

Findings:

  • Computed tomography (CT) revealed circumferential thickening of the colonic wall, predominantly on the left side.
  • Two patients exhibited heterogeneous mural enhancement, described as a target-sign appearance.

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  • Follow-up CT scans demonstrated resolution of the colonic wall thickening with conservative management.
  • Implications:

    • Glutaraldehyde-induced toxic colitis presents with clinical and radiologic features similar to colonic ischemia.
    • Healthcare providers should consider this complication in patients developing hemorrhagic colitis post-colonoscopy.