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Low platelet monoamine oxidase activity in pathological gambling
J L Carrasco1, J Sáiz-Ruiz, E Hollander
1Department of Psychiatry, Centro de Salud Mental, Parla Madrid, Spain.
Acta Psychiatrica Scandinavica
|December 1, 1994
Summary
Pathological gamblers exhibit significantly lower platelet monoamine oxidase (MAO) activity compared to healthy individuals. This finding suggests a link between MAO levels, impulse control, and sensation-seeking behaviors in gambling disorder.
Area of Science:
- Neuroscience
- Psychiatry
- Behavioral Science
Background:
- Decreased platelet monoamine oxidase (MAO) activity is linked to sensation-seeking traits and impulse control disorders.
- Pathological gambling is associated with both sensation-seeking and reduced impulse control.
Purpose of the Study:
- To investigate platelet monoamine oxidase (MAO) activity in pathological gamblers.
- To explore the relationship between MAO activity, sensation-seeking, and impulse control in pathological gambling.
Main Methods:
- Platelet MAO activity was measured in 15 pathological gamblers (DSM-III-R criteria).
- MAO levels were compared to those of 25 healthy controls.
- Sensation-seeking scores were assessed and correlated with MAO levels.
Main Results:
- Pathological gamblers showed significantly lower platelet MAO activity than controls.
- The range of MAO levels was significantly narrower in gamblers.
- MAO levels correlated negatively with sensation-seeking in controls, but not in gamblers.
Conclusions:
- Low platelet MAO activity is associated with pathological gambling, consistent with its link to impulse control disorders.
- Findings suggest potential therapeutic avenues for pathological gambling by targeting MAO activity or related pathways.