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Fetal thyrotoxicosis associated with nonimmune hydrops
1Department of Obstetrics and Gynecology, Sioux Valley Hospital, Sioux Falls, SD 57105.
American Journal of Obstetrics and Gynecology
|March 1, 1995
Summary
Fetal thyrotoxicosis can cause serious complications. This case highlights a twin pregnancy where one fetus developed nonimmune hydrops due to maternal Graves' disease and high antibody levels.
Area of Science:
- Obstetrics and Gynecology
- Endocrinology
- Fetal Medicine
Background:
- Thyrotoxicosis in pregnancy poses risks to fetal well-being.
- Graves' disease is an autoimmune condition affecting the thyroid.
- Thyroid-stimulating immunoglobulin G (TSIg) antibodies can cross the placenta.
Observation:
- A twin pregnancy involved a mother with a history of Graves' disease.
- The mother had elevated levels of TSIg antibodies.
- One twin presented with nonimmune hydrops fetalis.
Findings:
- Nonimmune hydrops fetalis developed in one fetus during a twin pregnancy.
- Maternal Graves' disease and high TSIg antibody levels were noted.
- The affected fetus experienced hydrops despite the mother being euthyroid.
Implications:
- This case underscores the importance of monitoring TSIg levels in pregnant patients with Graves' disease.
- It highlights a potential cause of nonimmune hydrops fetalis in twin gestations.
- Early detection and management are crucial for improving fetal outcomes in such cases.