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Chronic myelomonocytic leukemia following prolonged alkylating agent therapy for multiple myeloma
T Natazuka1, T Yamaguchi, T Murayama
1Department of Medicine, Kobe University School of Medicine, Japan.
International Journal of Hematology
|December 1, 1994
Abstract:
A 35-year-old male presented with chronic myelomonocytic leukemia (CMMoL) after 6.5 years of alkylating agent therapy for IgG-kappa type multiple myeloma. The total dose of melphalan was 0.648 g. CMMoL was stable with weekly injection of alpha-interferon for one year. Thereafter, monocytosis and thrombocytopenia aggravated, and the patient died of disseminating intravascular coagulation. Prolonged drug therapy can induce CMMoL, as well as other myelodysplastic syndromes.