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Hemostatic parameters and platelet activation by flow-cytometry in normal pregnancy: a longitudinal study
L Gatti1, P M Tenconi, D Guarneri
1Centro Trasfusionale e di Immunoematologia, Istituti Clinici di Perfezionamento, Milan, Italy.
International Journal of Clinical & Laboratory Research
|January 1, 1994
Summary
Pregnancy hemostasis shows stable protein C and antithrombin III levels, but decreasing protein S activity. Platelet activation remains normal throughout gestation, indicating normal coagulation function during pregnancy.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Physiology
Background:
- Hemostasis, the process of blood clotting, is crucial during pregnancy.
- Understanding changes in coagulation factors and platelet function is vital for maternal and fetal health.
Purpose of the Study:
- To investigate dynamic changes in key hemostatic parameters during pregnancy.
- To assess platelet activation and function across trimesters in uncomplicated pregnancies.
Main Methods:
- Studied 19 pregnant women across three trimesters.
- Measured prothrombin time, activated partial thromboplastin time, fibrinogen, antithrombin III, protein C, and protein S.
- Assessed platelet function using cytofluorimetry with anti-GPM-140 antibody.
Main Results:
- Fibrinogen levels increased steadily during pregnancy.
- Prothrombin time, activated partial thromboplastin time, protein C, and antithrombin III remained within normal ranges.
- Protein S activity decreased significantly throughout pregnancy, while platelet activation remained unchanged.
Conclusions:
- Pregnancy is associated with a significant decrease in protein S activity, independent of antigen levels.
- Key coagulation parameters and platelet function remain largely stable and within normal limits in uncomplicated pregnancies.