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Related Experiment Videos

Mast cell numbers in multiple dermatofibromas

T Yamamoto1, I Katayama, K Nishioka

  • 1Department of Dermatology, School of Medicine, Tokyo Medical and Dental University, Japan.

Dermatology (Basel, Switzerland)
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

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Mast cells may contribute to the development and worsening of multiple dermatofibromas (DFs) in patients with autoimmune disorders like systemic lupus erythematosus (SLE). Increased mast cells were observed in early-stage DFs, suggesting their role in fibrotic processes.

Area of Science:

  • Dermatology
  • Immunology
  • Pathology

Background:

  • Multiple dermatofibromas (DFs) are associated with various systemic disorders, particularly systemic lupus erythematosus (SLE).
  • The role of mast cells in the pathogenesis of multiple DFs in autoimmune conditions remains unclear.

Observation:

  • This study examined three patients with multiple DFs and positive antinuclear antibodies, including two with SLE and one with SLE and Sjögren syndrome.
  • Mast cell distribution and numbers were analyzed in excised DF lesions.

Findings:

  • Mast cell counts were significantly elevated in the upper portions of early-stage DFs in two out of three patients compared to solitary DFs, nevi, and normal skin.
  • The case with normal mast cell numbers presented with older, fading lesions.

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Implications:

  • Mast cells are implicated in the induction and exacerbation of fibrotic processes in multiple DFs.
  • These findings suggest that mast cells represent a reactive hyperplasia associated with systemic autoimmune disorders.